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NCEM

NCEM is a tool for the inference of cell-cell communication in spatial molecular data.

ncem concept

Manuscript

Please see our manuscript [Fischer et al., 2023] in Nature Biotechnology to learn more.

NCEM’s key application

  • Node-centric expression models (NCEMs) are proposed to improve cell communication inference by using spatial graphs of cells to constrain axes of cellular communication.

  • NCEMs can be used for cell communication inference captured with different spatial profiling technologies and are not limited to receptor-ligand signaling.

  • NCEMs can be applied to deconvoluted spot transcriptomics.

  • Dependencies inferred by NCEMs are directional.

Getting started with NCEM

You can install ncem via pip from PyPI:

$ pip install ncem

Contributing to NCEM

We are happy about any contributions! Before you start, check out our contributor guide.