NCEM
NCEM is a tool for the inference of cell-cell communication in spatial molecular data.

Manuscript
Please see our manuscript [Fischer et al., 2023] in Nature Biotechnology to learn more.
NCEM’s key application
Node-centric expression models (NCEMs) are proposed to improve cell communication inference by using spatial graphs of cells to constrain axes of cellular communication.
NCEMs can be used for cell communication inference captured with different spatial profiling technologies and are not limited to receptor-ligand signaling.
NCEMs can be applied to deconvoluted spot transcriptomics.
Dependencies inferred by NCEMs are directional.
Getting started with NCEM
You can install ncem via pip from PyPI:
$ pip install ncem
Contributing to NCEM
We are happy about any contributions! Before you start, check out our contributor guide.